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Concord: Lifesaving care for preterm babies improved by keeping the umbilical cord intact neonatal care, incubator, cord clamping
neonatal care, incubator, cord clamping
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A pre-targeting approach for liver radioembolisation radiation therapy, theranostics, radioembolisation, pre-targeting, interventional radiology, nuclear medicine, supramolecular chemistry, pharmaceutical industry, biotech/medical companies
radiation therapy, theranostics, radioembolisation, pre-targeting, interventional radiology, nuclear medicine, supramolecular chemistry, pharmaceutical industry, biotech/medical companies
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Imaging agents that specifically target peripheral nerves surgery, image guided surgery, imaging, nerves, pharmaceutical industry, biotech/medical companies
surgery, image guided surgery, imaging, nerves, pharmaceutical industry, biotech/medical companies
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DNA-Probe for Non-Destructive Chromatin Sequence Extraction (nodeChrose) human genetics, chromatin, purification, DNA, LNA, nucleic acid, DNA probe, oligonucleotide, single-molecule, sequencing
human genetics, chromatin, purification, DNA, LNA, nucleic acid, DNA probe, oligonucleotide, single-molecule, sequencing
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RNA-targeted therapy for von Willebrand Disease small interfering RNA, inherited bleeding disorder, von Willebrand’s factor, thrombocytopenia, bleeding, RNA-targeted therapy, immunology
small interfering RNA, inherited bleeding disorder, von Willebrand’s factor, thrombocytopenia, bleeding, RNA-targeted therapy, immunology
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Liposome drug delivery vector targeting the blood brain barrier pharmaceutical industry, biotech/medical companies, neuropharma, drug delivery platform
pharmaceutical industry, biotech/medical companies, neuropharma, drug delivery platform
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Method for generating PRRS vaccination strains arterivirus, PRRSV, swine, pig, vaccine, frameshift, antivirals
arterivirus, PRRSV, swine, pig, vaccine, frameshift, antivirals
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A direct, high throughput assay for Neutrophil extracellular traps (NETs) pharmaceutical industry, biotech/biomedical companies, autoimmune diseases
pharmaceutical industry, biotech/biomedical companies, autoimmune diseases
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Novel TGF Beta modulator in Osteoarthritis TGF beta, osteoarthritis, biomarker
TGF beta, osteoarthritis, biomarker
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Mouse models of spontaneous thrombosis animal model, mouse model, thrombosis, atherothrombosis, venous thrombosis
animal model, mouse model, thrombosis, atherothrombosis, venous thrombosis
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Improved superconductivity with periodic nano/micro patterning superconductors, transition temperature, nanopatterning, phononic structure, electronic structure, NMR, MRI
superconductors, transition temperature, nanopatterning, phononic structure, electronic structure, NMR, MRI
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Nanocapillary electrokinetic system for particle tracking / counting and microscopy particle count, nanoparticle, microparticle, particle tracking, flow cytometry, microparticle analysis, airborne particles, water analysis, vesicles, exosomes, colloids, liquid chromatography, microscopy, hollow fibre
particle count, nanoparticle, microparticle, particle tracking, flow cytometry, microparticle analysis, airborne particles, water analysis, vesicles, exosomes, colloids, liquid chromatography, microscopy, hollow fibre
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Atomically precise array of Nanopores in organic 2D membranes energy production, fuel cells, filter membranes
energy production, fuel cells, filter membranes
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Synthetic control on the tropism of cells as a means to enhance the efficacy of cell therapies cell therapy, cell imaging, biotech/medical companies,yropism, clinical, efficacy, synthetic control
cell therapy, cell imaging, biotech/medical companies,yropism, clinical, efficacy, synthetic control
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Plasma biomarker for detection of onset of chronic Rheumatoid Arthritis Rheumatoid Arthritis, biomarker, plasma
Rheumatoid Arthritis, biomarker, plasma
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Reversible immortalization method for generation of homogenous, stable & authentic human cell lines pharmaceutical industry, biotech/medical companies, cardiomyocytes, immortalisaton
pharmaceutical industry, biotech/medical companies, cardiomyocytes, immortalisaton
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Treatment of familial blindness gene therapy, virology, orphan diseases, biopharmaceuticals, eye
gene therapy, virology, orphan diseases, biopharmaceuticals, eye
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The development of therapeutics for CADASIL patients CNS, CADASIL, gene therapy, rare disease, orphan, exon skipping, oligonucleotides
CNS, CADASIL, gene therapy, rare disease, orphan, exon skipping, oligonucleotides
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The Netherlands Epidemiology of Obesity (NEO) Study Database and Biobank obesity, metabolomic disease, biobank
obesity, metabolomic disease, biobank
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Device to remove unwanted solvents from biochemical samples analytical (bio)chemistry, liquid chromatography, NMR
analytical (bio)chemistry, liquid chromatography, NMR
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Capillary transfer of single droplets analytical (bio)chemistry, LC-NMR, sample transfer
analytical (bio)chemistry, LC-NMR, sample transfer
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Power tool attachment to cut an oval shape in bone medical device, power tool, orthopedics, surgery, oncology
medical device, power tool, orthopedics, surgery, oncology
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Single atom graphene nanogap biomolecule detection, sequencing, spectroscopy
biomolecule detection, sequencing, spectroscopy
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Plasma antenna for MRI imaging, medical diagnostics, MRI
imaging, medical diagnostics, MRI
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Novel automated sample purification and enrichment for DI-MS analytical (bio)chemistry, mass spectroscopy
analytical (bio)chemistry, mass spectroscopy
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Fabrication of graphene nanopore/nanogap structures with implemented nanofluidic channel biomolecule detection, sequencing, electron tomography
biomolecule detection, sequencing, electron tomography
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Dynamic re-usable RAMAN scattering sensor chemistry, sensors, (bio)chemical analysis
chemistry, sensors, (bio)chemical analysis
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Wide Field SpectroPolarimetry remote sensing, air quality measurements, optics
remote sensing, air quality measurements, optics
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Natural ionic liquids and deep eutectic solvents compound extraction, compound solubilization, natural products, drug delivery, biopharmaceuticals
compound extraction, compound solubilization, natural products, drug delivery, biopharmaceuticals
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Reduction of antibiotic resistance - Co-administration of food-grade compounds antibiotics, antibiotic resistance, antibiotic adjuvant
antibiotics, antibiotic resistance, antibiotic adjuvant
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Mouse models available for Polycystic Kidney Disease (PKD) drug testing drug screening, PKD, kidney fibrosis, pharmacology
drug screening, PKD, kidney fibrosis, pharmacology
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High throughput 3D cell culture assay 3D cell culture, cell spheroids, high-throughput, drug screening, breast cancer, cancer
3D cell culture, cell spheroids, high-throughput, drug screening, breast cancer, cancer
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ApoE3Leiden Mouse obesity, diabetes, Artherosclerosis, brown fat, metabolic disease
obesity, diabetes, Artherosclerosis, brown fat, metabolic disease
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New mouse model, expressing human Fc receptors, to test the efficacy of therapeutic antibodies drug delivery, dermatology, cosmetics, antibodies, collaboration
drug delivery, dermatology, cosmetics, antibodies, collaboration
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Therapeutic intervention in Facioscapulohumeral muscular dystrophy (FSHD) muscular dystrophy, FSHD, research, gene therapy, epigenetic therapy, exon skipping, small molecule therapy
muscular dystrophy, FSHD, research, gene therapy, epigenetic therapy, exon skipping, small molecule therapy
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Increasing the efficacy of Vancomycin - Natural compounds to reduce resistance antibiotics, antibiotic resistance, antibiotic adjuvant, vancomycin
antibiotics, antibiotic resistance, antibiotic adjuvant, vancomycin
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New approach for oligonucleotide-mediated exon skipping in neurodegenerative diseases neurodegenerative diseases, exon skipping, SCA3,SCA1, DRPLA
neurodegenerative diseases, exon skipping, SCA3,SCA1, DRPLA
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Metal and Alloy Nanoparticle Production through Cathodic Corrosion alloy, antibacterial, catalysis, cathodic corrosion, colloidal, electrochemical methods, high purity, metal, metal alloy, metal nanoparticle, nanocomposite, nanoparticle, nanoparticle production, silver nanoparticle
alloy, antibacterial, catalysis, cathodic corrosion, colloidal, electrochemical methods, high purity, metal, metal alloy, metal nanoparticle, nanocomposite, nanoparticle, nanoparticle production, silver nanoparticle
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Adjuvant Compounds for Conjugated Synthetic Vaccines adjuvant, agonist, cell, activation, immune response, immunological ligands, synthetic vaccine
adjuvant, agonist, cell, activation, immune response, immunological ligands, synthetic vaccine
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Reconstructed Human Skin Models for Research and Screening Purposes dermatology, skin, keratinocytes, fibroblasts, melanocytes, wound healing, infection, eczema, cancer, penetration, irritation
dermatology, skin, keratinocytes, fibroblasts, melanocytes, wound healing, infection, eczema, cancer, penetration, irritation
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Imaging tools to characterise migration and interaction of parasites within their host parasite, malaria, vaccine, molecular imaging, formulation, parasites, fluorescence, schistosoma, hookworm, bacteria
parasite, malaria, vaccine, molecular imaging, formulation, parasites, fluorescence, schistosoma, hookworm, bacteria
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Platinum metal-based anticancer and antibacterial drugs metallodrugs, bacteria, cancer, pharmaceutical industry, biotech/medical companies
metallodrugs, bacteria, cancer, pharmaceutical industry, biotech/medical companies
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Novel approach to conjugate adjuvants to live-attenuated vaccines parasite, malaria, vaccine, molecular imaging, formulation, parasites, fluorescence, schistosoma, hookworm, bacteria
parasite, malaria, vaccine, molecular imaging, formulation, parasites, fluorescence, schistosoma, hookworm, bacteria
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Photo activated cancer prodrug metallodrugs, light activation, drug delivery, prodrugs, pharmaceutical industry, biotech/medical companies
metallodrugs, light activation, drug delivery, prodrugs, pharmaceutical industry, biotech/medical companies
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Reconstructed Human Skin Models for Research and Screening Purposes Four human skin equivalents that can be used for predictive screening or contract research that requires the complexity of human skin.
Four human skin equivalents that can be used for predictive screening or contract research that requires the complexity of human skin.
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Novel Pharmacologial Chaperones for Improved Enzyme Replacement Therapy A small molecule with potential to be used as part of a new treatment for Fabry patients in combination with enzyme replacement therapy.
A small molecule with potential to be used as part of a new treatment for Fabry patients in combination with enzyme replacement therapy.
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Proteomining: An Integrated Approach to Mine for Novel Bioactive Compounds Produced by Actinomycetes Exploits the application of genome sequencing with metabolite identification methods, activity assays and proteomics or RNAsequencing.
Exploits the application of genome sequencing with metabolite identification methods, activity assays and proteomics or RNAsequencing.
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Type 1 Diabetes Neo-Epitopes: Autoimmunity Against a Defective Ribosomal Insulin Gene Product A new neo-epitope generated by defective ribosomal products (DRiPs) from the proinsulin gene.
A new neo-epitope generated by defective ribosomal products (DRiPs) from the proinsulin gene.
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Ubiquitin Variants as Antiviral Agents Structurally diverse, virus-specific deubiquitinating enzymes can be selectively targeted through rational protein design technology.
Structurally diverse, virus-specific deubiquitinating enzymes can be selectively targeted through rational protein design technology.
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Adjuvant Compounds for Conjugated Synthetic Vaccines Compounds which retain their strong adjuvanticity upon conjugation but possess much improved physicochemical properties
Compounds which retain their strong adjuvanticity upon conjugation but possess much improved physicochemical properties
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Metal and Alloy Nanoparticle Production through Cathodic Corrosion A radically different method for large scale production of diverse metal nanoparticles and their alloys
A radically different method for large scale production of diverse metal nanoparticles and their alloys
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DNA-Probe for Non-Destructive Chromatin Sequence Extraction (nodeChrose) This technology can select and “pull down” sequence-specific chromatin fragments using a non-destructive, non-denaturing method
This technology can select and “pull down” sequence-specific chromatin fragments using a non-destructive, non-denaturing method
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Platinum Metal-Based Anticancer and Antibacterial Drugs Novel palladium, platinum, and gold compounds that may be used as anticancer or antibacterial agents
Novel palladium, platinum, and gold compounds that may be used as anticancer or antibacterial agents
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Novel Approach to Conjugate Adjuvants to Live-Attenuated Vaccines A novel adjuvant technology, that amplifies the interaction of the live-attenuated (sporozoite) vaccine with the host immune system.
A novel adjuvant technology, that amplifies the interaction of the live-attenuated (sporozoite) vaccine with the host immune system.
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Imaging Tools to Characterise Migration and Interaction of Parasites within their Host A molecular imaging technology that uses a fluorescent/radioactive tracer to label parasites.
A molecular imaging technology that uses a fluorescent/radioactive tracer to label parasites.
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A Pre-Targeting Approach for Liver Radioembolisation A two-step pre-targeting approach for radiation therapy with increased accuracy which is less prone to toxic side-effects.
A two-step pre-targeting approach for radiation therapy with increased accuracy which is less prone to toxic side-effects.
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Imaging Agents that Specifically Target Peripheral Nerves A peptide-based imaging agent that specifically binds to peripheral nerves, suitable for use in fluorescence-guided surgery application.
A peptide-based imaging agent that specifically binds to peripheral nerves, suitable for use in fluorescence-guided surgery application.
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Photoactivatable Anticancer Prodrug A novel photo activated anticancer prodrug consisting in a rigidin analogue caged by a ruthenium polypyridyl complex
A novel photo activated anticancer prodrug consisting in a rigidin analogue caged by a ruthenium polypyridyl complex
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Improved Superconductivity with Periodic Nano/Micro Patterning Improving superconducting materials resulting in a controlled modification of the phononic and electronic structure of thin films
Improving superconducting materials resulting in a controlled modification of the phononic and electronic structure of thin films
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Nanocapillary Electrokinetic System for Particle Tracking / Counting and Microscopy An affordable platform capable of detecting, tracking, counting, and measuring single nanoparticles, vesicles, and biomolecules
An affordable platform capable of detecting, tracking, counting, and measuring single nanoparticles, vesicles, and biomolecules
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Single Atom Graphene Nanogap A method yielding a device separating two single carbon atoms from two individual conducting graphene layers
A method yielding a device separating two single carbon atoms from two individual conducting graphene layers
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Concord: Lifesaving Care for Preterm Babies Improved by Keeping the Umbilical Cord Intact An innovative resuscitation table enabling all care needed to stabilize a preterm baby while the umbilical cord remains intact.
An innovative resuscitation table enabling all care needed to stabilize a preterm baby while the umbilical cord remains intact.
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Fabrication of Graphene Nanopore/Nanogap Structures with Implemented Nanofluidic Channel A new technique for the fabrication of nanogap devices which is considerably faster than conventional methods
A new technique for the fabrication of nanogap devices which is considerably faster than conventional methods
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Liposome Drug Delivery Vector Targeting the Blood Brain Barrier A lipid, which when mixed with a naturally occurring phospholipid and formulated into 100 nm liposomes, results in a drug delivery vehicle
A lipid, which when mixed with a naturally occurring phospholipid and formulated into 100 nm liposomes, results in a drug delivery vehicle
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High Throughput 3D Cell Culture Assay An automated method to create 3D ECM-embedded cell spheroids that overcomes previously identified limitations
An automated method to create 3D ECM-embedded cell spheroids that overcomes previously identified limitations
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Reduction of Antibiotic Resistance-Co-Administration of Food-Grade Compounds Scientists at Leiden University's Institute of Biology have found compounds that reduce antibiotic resistance in pathogenic bacteria
Scientists at Leiden University's Institute of Biology have found compounds that reduce antibiotic resistance in pathogenic bacteria
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Natural Ionic Liquids and Deep Eutectic Solvents Researchers from Leiden University and colleagues from Delft have identified novel natural ionic liquids and deep eutectic solvents (NADES).
Researchers from Leiden University and colleagues from Delft have identified novel natural ionic liquids and deep eutectic solvents (NADES).
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Dynamic Re-usable RAMAN Scattering Sensor This SERS-based sensor allows for dynamical and re-usable measurements and can be used with standard RAMAN equipment
This SERS-based sensor allows for dynamical and re-usable measurements and can be used with standard RAMAN equipment
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Capillary Transfer of Single Droplets Scientists of Leiden University have developed an apparatus to transfer droplets from a first capillary to a second capillary
Scientists of Leiden University have developed an apparatus to transfer droplets from a first capillary to a second capillary
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Device to Remove Unwanted Solvents from Biochemical Samples A simple and robust approach to efficiently remove unwanted solvents from liquid mixtures containing dissolved chemical components
A simple and robust approach to efficiently remove unwanted solvents from liquid mixtures containing dissolved chemical components
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Increasing the Efficacy of Vancomycin: Natural Compounds to Reduce Resistance A compound that decreases the resistance of vancomycin-resistant bacteria
A compound that decreases the resistance of vancomycin-resistant bacteria
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Mouse Models of Spontaneous Thrombosis A mouse model for VT or AT via “humanizing” mouse coagulation via RNAi of the hepatic antithrombin and protein C genes.
A mouse model for VT or AT via “humanizing” mouse coagulation via RNAi of the hepatic antithrombin and protein C genes.
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Method for Generating PRRS Vaccination Strains Arteriviruses that display reduced translation and function of nsp2TF, as well as the vaccines and immunogenic compositions.
Arteriviruses that display reduced translation and function of nsp2TF, as well as the vaccines and immunogenic compositions.
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Synthetic Control on the Tropism of Cells as a means to Enhance the Efficacy of Cell Therapies Using a pre-targeting approach, abundant membrane receptors on a therapeutic cell can be converted into binders of a multivalent cyclodex.
Using a pre-targeting approach, abundant membrane receptors on a therapeutic cell can be converted into binders of a multivalent cyclodex.
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Therapeutic Intervention in Facioscapulohumeral Muscular Dystrophy (FSHD) Novel target mechanisms and in vitro and in vivo models for the development of therapeutic interventions in Facioscapulohumeral Muscular Dystrophy.
Novel target mechanisms and in vitro and in vivo models for the development of therapeutic interventions in Facioscapulohumeral Muscular Dystrophy.
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ApoE3Leiden Mouse The APOE3Leiden mouse displays a human-like plasma lipid profile and is sensitive to diet-induced hyperlipidemia among other illnesses.
The APOE3Leiden mouse displays a human-like plasma lipid profile and is sensitive to diet-induced hyperlipidemia among other illnesses.
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The Development of Therapeutics for CADASIL Patients A potential method for the therapeutic intervention in patients suffering from CADASIL.
A potential method for the therapeutic intervention in patients suffering from CADASIL.
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The Netherlands Epidemiology of Obesity (NEO) Study Database and Biobank Information from 6,000 obese participants from the Netherlands was gathered over a four-year period with a goal of aiding researchers.
Information from 6,000 obese participants from the Netherlands was gathered over a four-year period with a goal of aiding researchers.
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New Fixatives with 15-Fold Lower Formaldehyde Concentration Two low-hazardous alternatives to formalin 10% with 10- to 15-fold lower formaldehyde concentration and no change to your histopathology protocol.
Two low-hazardous alternatives to formalin 10% with 10- to 15-fold lower formaldehyde concentration and no change to your histopathology protocol.
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Retractable Needle A needle and sheet system that automatically retracts when contact is made with blood.
A needle and sheet system that automatically retracts when contact is made with blood.
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Use of 6'-Fluoro-Neplanocin A Derivatives Against Chikungunya Virus Identification of antiviral molecules for the development of therapeutic drugs to treat patients suffering from Chikungunya virus infection.
Identification of antiviral molecules for the development of therapeutic drugs to treat patients suffering from Chikungunya virus infection.
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Reversible Immortalization Method for the Generation of Homogenous Stable Authentic Human Cell Lines Method that allows expansion and redifferentiation of a large population of homogenous, differentiated authentic cells.
Method that allows expansion and redifferentiation of a large population of homogenous, differentiated authentic cells.
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Supramolecular Materials for 3D Cell Culture of Induced Pluripotent Stem Cells and their Derivative Scientists at Leiden University have found a self-assembled squaramide-based tripodal hydrogel for use as a material in cell culture.
Scientists at Leiden University have found a self-assembled squaramide-based tripodal hydrogel for use as a material in cell culture.
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Novel alpha-Glucosidase and alpha-Galactosidase Inhibitors as Antidiabetic, Antiviral Drugs and as Pharmacological Chaperones for Pompe Disease Small molecules that react reversibly or irreversibly with human α-glucosidases depending on nitrogen position of the cyclic sulfamidate.
Small molecules that react reversibly or irreversibly with human α-glucosidases depending on nitrogen position of the cyclic sulfamidate.
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test case Vaccine vaccine
Vaccine vaccine
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TARGETED COMPLEMENT INHIBITION We have developed strategies to target complement inhibition to specific tissues / cells to achieve local complement inhibition while leaving the systemic complement pool available to fight infections and achieve homeostasis.
We have developed strategies to target complement inhibition to specific tissues / cells to achieve local complement inhibition while leaving the systemic complement pool available to fight infections and achieve homeostasis.
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Service Offered: High-Throughput Profiling of Protein N-Glycosylation Employing Linkage-Specific Sialic Acid Esterfication The team of Professor Manfred Wuhrer at Leiden University Medical Center (LUMC), have developed a rapid, robust and linkage-specific high-throughput method for sialic acid stabilization and analysis of complex glycoprotein mixtures such as human plasma N-glycome.
The team of Professor Manfred Wuhrer at Leiden University Medical Center (LUMC), have developed a rapid, robust and linkage-specific high-throughput method for sialic acid stabilization and analysis of complex glycoprotein mixtures such as human plasma N-glycome.
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Service Offered: Cell Model of Immune Responses Scientists at Leiden University Medical Center (LUMC), have developed a dendritic cell culture system as a read-out of the immune response and as a replacement for animal testing.
Scientists at Leiden University Medical Center (LUMC), have developed a dendritic cell culture system as a read-out of the immune response and as a replacement for animal testing.
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Tumor Associated Carbohydrate Antigens as Targets for Colorectal Cancer Immunotherapy The present invention relates to a novel method to identify highly specific tumor associated carbohydrate antigens (TACAs) derived from colorectal cancer (CRC) tissue.
The present invention relates to a novel method to identify highly specific tumor associated carbohydrate antigens (TACAs) derived from colorectal cancer (CRC) tissue.
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Immunomodulatory Capacity and Therapeutic Potential of S.mansoni-Derived Proteins in the Context of Immune Modulation, Asthma and/or Allergy Proteomics analysis on several fractions was performed and identified a number of unique proteins of which some were highly abundant. Identification of unique Breg-inducing molecules may form interesting treatment targets for inflammatory diseases such as asthma or allergies.
Proteomics analysis on several fractions was performed and identified a number of unique proteins of which some were highly abundant. Identification of unique Breg-inducing molecules may form interesting treatment targets for inflammatory diseases such as asthma or allergies.
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Cytotoxicity of Synthesized EPD (EPD-S), A Natural Sesquiterpene Lacton, and its Future Clinical Efficacy The present invention is relating to a new anti-cancer drug, EPD-S. This drug shows on itself, as well as in combination with paclitaxel and cisplatin, strong cytotoxicity against ovarian cancer and other cancer types.
The present invention is relating to a new anti-cancer drug, EPD-S. This drug shows on itself, as well as in combination with paclitaxel and cisplatin, strong cytotoxicity against ovarian cancer and other cancer types.
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Targeting ligand-bound (solid-phase) C1q We have recently developed recombinant fully human antibodies that strongly bind to C1q that is bound to its ligands (solid-phase) but does not bind to circulating C1q.
We have recently developed recombinant fully human antibodies that strongly bind to C1q that is bound to its ligands (solid-phase) but does not bind to circulating C1q.
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Targeted Complement Inhibition We have developed strategies to target complement inhibition to specific tissues / cells to achieve local complement inhibition while leaving the systemic complement pool available to fight infections and achieve homeostasis.
We have developed strategies to target complement inhibition to specific tissues / cells to achieve local complement inhibition while leaving the systemic complement pool available to fight infections and achieve homeostasis.
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ANTISENSE OLIGONUCLEOTIDE THERAPY FOR HUNTINGTON’S DISEASE:
 
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ANTISENSE OLIGONUCLEOTIDE THERAPY FOR D-CAA AND ALZHEIMER'S DISEASE:
 
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ANTISENSE OLIGONUCLEOTIDE THERAPY FOR HUNTINGTON’S DISEASE Leiden University Medical Center's NeuroD research group has developed an antisense oligonucleotide (ASO) therapy for Huntington's Disease (HD), targeting the disease-causing HTT transcript. This novel therapy aims to reduce the toxicity of mutant HTT protein while preserving the vital functions of the normal protein, and has demonstrated improvement in symptoms in an HD mouse model, marking a significant advance in HD treatment.
Leiden University Medical Center's NeuroD research group has developed an antisense oligonucleotide (ASO) therapy for Huntington's Disease (HD), targeting the disease-causing HTT transcript. This novel therapy aims to reduce the toxicity of mutant HTT protein while preserving the vital functions of the normal protein, and has demonstrated improvement in symptoms in an HD mouse model, marking a significant advance in HD treatment.
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ANTISENSE OLIGONUCLEOTIDE THERAPY FOR D-CAA AND ALZHEIMER'S DISEASE Leiden University Medical Center's NeuroD research group has developed an innovative antisense oligonucleotide (ASO) therapy targeting APP gene mutations, applicable to D-CAA and Alzheimer's Disease (AD). This therapy is designed to modulate APP pre-mRNA splicing, reducing harmful amyloid-beta production.
Leiden University Medical Center's NeuroD research group has developed an innovative antisense oligonucleotide (ASO) therapy targeting APP gene mutations, applicable to D-CAA and Alzheimer's Disease (AD). This therapy is designed to modulate APP pre-mRNA splicing, reducing harmful amyloid-beta production.
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LAHR: IMPROVED GENOME EDITING ACCURACY AND EFFICIENCY The present invention, termed Ligation-Assisted Homologous Recombination (LAHR), represents an innovative genome editing strategy that combines the genome editing capabilities of CRISPR/Cas12a technology with the high-fidelity of a dual repair mechanism. This method significantly enhances the efficiency and precision of introducing specific nucleotide substitutions while minimizing off-target effects, offering a promising approach for gene therapy and biomedical research.
The present invention, termed Ligation-Assisted Homologous Recombination (LAHR), represents an innovative genome editing strategy that combines the genome editing capabilities of CRISPR/Cas12a technology with the high-fidelity of a dual repair mechanism. This method significantly enhances the efficiency and precision of introducing specific nucleotide substitutions while minimizing off-target effects, offering a promising approach for gene therapy and biomedical research.
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Safe structural glass elements
 
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A memristor based on electromigration in a metal alloy
 
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From Wastewater to sustainable paper sizing
 
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Cheap oscillator delivers top performance
 
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PowerWindow, a clean energy-producing window
 
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Silicon transitors on plastic foils
 
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Multi Mode Grasper is all-round, smart and intuitive
 
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New method to control release of active substance
 
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Biobased membrane compund portects contrecte from drying
 
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Self healing concrete-materials that can repair itself
 
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Flexible Grasper: Perfect Balance between Sensitivity and Force
 
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Passive compensation of a tram's stray magnetic fields
 
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BLISP makes mobile devices more energy efficient
 
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Highly effective drag reduction system
 
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Detection method for squats
 
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Functional Drug Sensitivity Assays on Human Tumor Slices
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Serum Biomarker for Encapsulating Peritoneal Sclerosis
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Novel Extracellular Vesicle Quantification Assay for Scientific and Diagnostic Use
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Mouse Model for Aging-Associated Osteoporosis
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Inducible Transgenic Mouse Model to Study Intestinal Biology
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Lumbar Ultrasound Localizer
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Combined Therapy for Neuroendocrine Tumors
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Diagnostic Method of Pathogenic Variants in Monogenic Diseases
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Mouse Model for Cystic Fibrosis ΔF508 CFTR Mutation
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CHTOP Polyclonal Antibody
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Protein Expression and Purification Protocols
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Conditional Fmr1 Knockout Mouse Model for Fragile X Syndrome
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New Fmr1 Knockout Mouse Model for Fragile X Syndrome
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Panel of Anti-Estrogen Resistant Breast Cancer Cell Lines
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Inducible Mouse Model to Study FXTAS Progression and Reversibility
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CGG Repeat Knock-in Mouse Model for Fragile X Premutation and FXTAS
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Novel Models for Neutropenia in Shwachman-Diamond Syndrome
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Anti-Interleukin 17 receptor (IL-17R) Antibodies and Suicidal Ideation
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The Reciprocal Insufflator
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Highly Effective Treatment of Cardiac Arrhythmias with less side-effects
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Conditional Knock-out Mouse Model to Study Prostate Cancer Progression
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Preclinical Models for Drug Development in Human Prostate Cancer
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New Chronic Lymphocytic Leukemia Cell Line for Drug Development
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Novel Prostate Cander-Specific Anti-PSMA Nanobody and Nanobody Library
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New Synchronizable Hepatocyte Cell Line for Chronotoxicology
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New Hepatic Cell Line for Toxicology, Pharmacology and Drug Development
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Immunomodulation by MSC-like Material
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Cell Line Expressing Recombinant Human Anti- Müllerian Hormone
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Novel Herpes Simplex Virys Type 1 Vaccine to Treat and Prevent Infection
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A Zebrafish Model dor Defective CSF1R Signaling and Macrophage-Deficiency
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Highly Sensitive Bioassay for Measuring Insulin Bioactivity in Serum
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New Hepatocyte Cell Line for Toxicology, Pharmacology and Drug Development
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Novel Prostate Cancer-Specific Anti-PSMA Nanobody and Nanobody Library
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CHFR methylation for prediction disease outcome in stage II colorectal cancer
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LY75 methylation for prediction disease outcome in melanoma
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Streptococcus pneumoniae as a method for treatment of non-alcoholic steatohepatitis
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uitkomstmaat: Één objectieve functioneringsmeetlat: “Hoeveel beter word ik van de zorg in het ziekenhuis?”
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GABARAPL: Reducing the risk of tumor progression
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IL2: The use of IL-2 to prevent fetal gut injury
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Biomarker for Pediatric Liver Disease
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AMC Esophagus bank
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New drug candidates for lysosomal storage disorders, parkinsonism and type 2 diabetes
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MIC therapy: New topical immune modulating therapy against melanoma
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Abuse Potential Evaluation with Pharmaco-MRI
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Novel insight into drug action in the central nervous system using pharmacological MRI
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Applying histatin 1 to improve integration of dental implants
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SURPASS: SURgical PAtient Safety System, a digital checklist that can reduce up to 50% of peri-operative procedure related deaths
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Novel insights into neuroinflammatory diseases from studying freshly isolated human microglia and CNS surveilling T cells
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INHIBODY©: an ultra-specific labeling tool for measuring active glucocerebrosidase in Gaucher patients and determining the biodistribution of therapeutic enzyme
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Normalization panels for RT-qPCR experiments on circulating miRNAs
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miRNA biomarker predicting aspirin insensitivity in patients at risk of recurrent cardiovascular events
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Convolutional neural network architecture with excellent performance on small data for image recognition
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Classification of sepsis patients as 4 blood genomic endotypes with prognostic and pathophysiological implications
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A new dual-action medication to cause double-trouble for Tuberculosis
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Method for identifying individuals at high risk of developing arthritis
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Cellulose as Raw Material
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Miniature sensors for detecting specific molecules
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Sunscreen: Just add water...
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New material for enriching phosphorylated proteins
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Colloidal microstructure design by shear and aggregation
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Efficient conversion of CO2 to CO
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Warm-White Light Source by Silicon Nanocrystals
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Reesink biomarker for functional cure of chronic HBV infection
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Absolute sizing and label-free identification of nanoparticles by flow cytometry
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Vibrational Circular Dichroism
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Fall army worm pest control in Africa
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Nanocrystal opto-electronic layers
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Classification of sepsis patients as four blood genomic endotypes with prognostic and pathophysiological implications
Plant varieties
Wageningen University & Research licenses proprietary plant varieties of fruits and arable crops, ornamentals, mushrooms and woody crops developed in dedicated breeding programs.
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Measurement equipment hemispherical light transmission of transparent materials
Wageningen Plant Research Horticulture is seeking commercial partners interested in commercialising measurement equipment for determining the hemispherical light transmission of transparent materials such as structured glass, textiles, plastics.
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Pasta highly enriched with vegetables
Wageningen University is seeking commercial partners interested in producing and commercializing pasta with high vegetable content.
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Plants with modified vascular tissue
Wageningen University & Research is seeking commercial partners interested in applications for plants with modified vascular tissue.
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Bacterial soft rot resistance
Wageningen University is seeking commercial partners interested in developing plant varieties containing a novel gene that confers resistance to bacterial soft rot.
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Resistance against parasitic weeds
Wageningen University is seeking commercial partners interested in developing plant varieties having enhanced resistance to parasitic weeds and/or other methods to control them.
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Improving Crop Yield under Zinc Limiting Conditions
Wageningen University is seeking commercial partners interested in developing plant varieties containing novel genes that regulate the hyper accumulation of zinc. Applications include adaptation to zinc deficiency, phytoremediation and/or bio-fortification.
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New method for the production of the compounds with anti-cancer activity, Arglabin and Parthenolide
Wageningen University is seeking commercial partners interested in producing the anti-cancer compounds Parthenolide, Hydroxy-Parthenolide and Arglabin through microbial production platforms and/or plants expressing their biosynthesis genes.
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Antiviral RNA compounds against Influenza viruses
Wageningen University is seeking commercial partners interested in developing a new class of antiviral drugs based on RNA compounds able to reduce viral replication levels and potentially applicable to all Influenza viruses, including new pandemic strains.
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Technology Offer Plant varieties
Wageningen University & Research licenses proprietary plant varieties of fruits and arable crops, ornamentals, mushrooms and woody crops developed in dedicated breeding programs.
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Technology Offer Unique separation technology: tasty juice, with less sugar and acid
Experts at Wageningen Food & Biobased Research have developed an innovative separation technology enabling both sugar and acids to be removed simultaneously from juice (fresh and diluted puree) while still preserving the sugar-acid balance, aroma and flavour. Wageningen University & Research is offering interested parties the opportunity to apply this unique technology to their production process.
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Technology Offer Improving Crop Yield under Zinc Limiting Conditions
Wageningen University & Research is seeking commercial partners interested in developing plant varieties containing novel genes that regulate the hyper accumulation of zinc. Applications include adaptation to zinc deficiency, phytoremediation and/or bio-fortification.
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Technology Offer Thermostable Cas9 Nucleases
The ultimate aim of plant breeding has always been to make plants resistant to drought and diseases. That could help eliminate hunger around the world. This is no longer a distant thought, thanks to a technology called CRISPR-Cas. Today Wageningen University & Research (WUR) announces it will provide potential partners with free licenses to work on its patented CRISPR technology. The license must be applied to gene-editing of plants for non-profit applications. “We hope this contributes to healthier, more sustainable, equitable, affordable and resilient food production for all”, says WUR President prof. dr. ir. Louise O. Fresco.
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Cardiac coronary artery bypass implant
 
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Julius Research Toolbox
 
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IL4-IL10 Synerkine for treating OA
 
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Novel CD20 mAbs
 
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